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- Leslie Bibb as Kate Bohr, a country club wife from Austin, Texas, one of three longtime friends reuniting on a girls' trip
- Carrie Coon as Laurie Duffy, a corporate lawyer and recent divorcée from New York, one of three longtime friends reuniting on a girls' trip
- Walton Goggins as Rick Hatchett, a rugged and mysterious man with a chip on his shoulder, traveling with his young girlfriend Chelsea
- Sarah Catherine Hook as Piper Ratliff, a college senior studying religion and middle child of Timothy and Victoria
- Jason Isaacs as Timothy Ratliff, a financier in jeopardy from Durham, North Carolina, vacationing with his wife, Victoria, and kids Saxon, Piper, and Lochlan
- Lalisa Manobal as Thidapon "Mook" Sornsin, a health mentor for guests of the White Lotus
- Michelle Monaghan as Jaclyn Lemon, a successful television actress based in Hollywood, one of three longtime friends reuniting on a girls' trip
- Sam Nivola as Lochlan Ratliff, a shy high school senior and Timothy and Victoria's youngest child
- Lek Patravadi as Sritala Hollinger, one of the owners of the White Lotus, who pioneered its health program
- Parker Posey as Victoria Ratliff, Timothy's wife and mother to Saxon, Piper, and Lochlan
- Natasha Rothwell as Belinda Lindsey, a spa manager from the White Lotus in Hawaii, attending a work exchange. Rothwell reprises her role from the first season.
- Patrick Schwarzenegger as Saxon Ratliff, Timothy and Victoria's oldest child, who works for his father's company
- Tayme Thapthimthong as Gaitok, a security guard at the White Lotus
- Aimee Lou Wood as Chelsea, a bubbly free spirit from Manchester traveling with Rick, her much older boyfriend
- Jon Gries as "Gary" / Greg Hunt, a man involved with Chloe and the widower of Tanya McQuoid. Gries reprises his role from the first and second seasons.
Who Will Win Your Heart on The White Lotus Season 3?
